Health & Heal Flow Defend™ — Nattokinase, Serrapeptase & Lumbrokinase Enzyme Complex

A professional-grade systemic enzyme complex delivering Nattokinase (4,000 FU), Serrapeptase (120,000 SPUs), and Lumbrokinase alongside CoQ10, turmeric curcumin, rutin, bromelain, and amla — formulated to support healthy circulation, vascular flexibility, cardiovascular function, and the body's natural inflammatory response as part of a balanced lifestyle.

Flow Defend™ is built around three of the most clinically researched fibrinolytic and proteolytic enzymes available in supplemental form. Unlike digestive enzymes that act solely in the gastrointestinal tract, systemic enzymes are absorbed intact into the bloodstream where they exert their activity on proteins, fibrin, and inflammatory mediators at the systemic level. The combination of nattokinase, serrapeptase, and lumbrokinase provides overlapping and complementary fibrinolytic activity — each working via distinct but synergistic mechanisms to support circulatory and vascular health.

Key Ingredients & Mechanisms

• Nattokinase — 4,000 FU per serving
  A serine protease derived from natto (fermented soy), nattokinase is the most extensively researched fibrinolytic enzyme in supplemental use. It directly degrades fibrin — the protein scaffold of blood clots — and has been shown in clinical studies to support healthy blood viscosity, vascular tone, and circulatory efficiency. The 4,000 FU dose reflects the therapeutic range used in published clinical trials.
• Serrapeptase — 120,000 SPUs per serving
  A metalloprotease originally derived from Serratia marcescens bacteria found in the gut of silkworms. Serrapeptase breaks down non-living protein matter including fibrin, dead tissue, and certain inflammatory proteins, and has been studied for its role in supporting tissue comfort, vascular health, and the resolution of the normal inflammatory response. The 120,000 SPU dose is at the upper range used in clinical research.
• Lumbrokinase
  A complex of fibrinolytic enzymes derived from Lumbricus rubellus (earthworm extract), used in traditional Chinese medicine and now the subject of growing clinical research. Lumbrokinase works via a distinct fibrinolytic pathway from nattokinase, providing complementary activity that broadens the circulatory support profile of this formula.
• Coenzyme Q10 (CoQ10)
  A fat-soluble antioxidant and mitochondrial cofactor essential for ATP synthesis in cardiac and vascular smooth muscle cells. CoQ10 levels decline with age and with statin use; supplementation supports cardiovascular energy metabolism and vascular antioxidant defence.
• Turmeric Extract (Curcuma longa)
  Standardised for curcuminoids — potent polyphenolic anti-inflammatory compounds that inhibit NF-κB signalling and COX-2 enzyme activity, supporting the resolution of the body's normal inflammatory response at the cellular level.
• Rutin (Quercetin glycoside)
  A bioflavonoid that supports capillary integrity and vascular permeability. Rutin inhibits platelet aggregation via a distinct mechanism and works synergistically with nattokinase and serrapeptase to support microcirculation.
• Bromelain
  A proteolytic enzyme complex derived from pineapple stem, bromelain has broad anti-inflammatory and fibrinolytic activity and enhances the bioavailability of curcumin and rutin when co-administered.
• Amla (Indian Gooseberry, Emblica officinalis)
  One of the richest natural sources of vitamin C and polyphenols including emblicanin A and B. Amla provides antioxidant support for vascular endothelium and supports healthy lipid oxidation markers.

Formulated to Support

• Healthy blood flow, circulation, and vascular function
• Fibrin metabolism and healthy blood viscosity within normal ranges
• Arterial flexibility and vascular smooth muscle tone
• The body's natural inflammatory response and resolution
• Cardiovascular energy metabolism via CoQ10
• Capillary integrity and microcirculation
• Antioxidant protection of vascular endothelium

Why an Enteric-Coated Capsule?

Systemic enzymes must survive the acidic environment of the stomach intact to be absorbed in the small intestine. Without enteric coating, proteolytic enzymes like serrapeptase and nattokinase are denatured by stomach acid before they can be absorbed. The enteric-coated capsule in this formula ensures enzymes pass through the stomach undamaged and are released in the alkaline environment of the small intestine, where they are absorbed systemically.

How to Use

Take as directed on the product label. For optimal systemic enzyme absorption, take on an empty stomach at least 30–45 minutes before meals or 2 hours after eating. Do not crush or chew — the enteric coating is essential for efficacy. Evening use away from food is a common protocol for systemic enzyme therapy.

Product Specifications

• Enteric-coated capsule — protects enzyme activity through gastric transit
• Non-GMO, gluten-free
• No artificial fillers or flow agents
• Manufactured in a GMP-certified facility to TGA-compliant standards

Frequently Asked Questions

What are systemic enzymes and how are they different from digestive enzymes?
Digestive enzymes (like standard bromelain, lipase, amylase) are taken with food and act within the gastrointestinal tract to break down nutrients. Systemic enzymes are enteric-coated to survive stomach acid and are absorbed intact into the bloodstream, where they act systemically — breaking down fibrin, modulating inflammatory mediators, and supporting vascular health at the circulatory level. Flow Defend™ is a systemic enzyme formula, not a digestive enzyme supplement.

What is fibrin and why does it matter for circulation?
Fibrin is an insoluble protein formed during the coagulation cascade that creates the structural mesh of blood clots. While essential for wound repair, excess fibrin accumulation in the vascular system is associated with reduced blood fluidity and impaired circulation. Fibrinolytic enzymes like nattokinase and lumbrokinase support the body's natural fibrin clearance mechanisms, helping maintain healthy blood viscosity and vascular flow.

Can I take this with cardiovascular medications?
Nattokinase, serrapeptase, and lumbrokinase all have fibrinolytic and anticoagulant activity that may potentiate the effects of anticoagulant medications (warfarin, rivaroxaban, apixaban), antiplatelet drugs (aspirin, clopidogrel), and certain cardiovascular medicines. This combination must not be taken alongside blood thinners without explicit medical supervision. Consult a qualified healthcare professional before use if you are taking any cardiovascular prescription medicines.

How long before I notice circulatory benefits?
Systemic enzyme therapy is cumulative. Most practitioners recommend a minimum of 6–12 weeks of consistent use before assessing outcomes. Initial benefits related to tissue comfort and general vitality may be noticed sooner in some individuals.

Why is CoQ10 included in a circulation formula?
The heart and arterial smooth muscle have among the highest energy demands of any tissue in the body. CoQ10 is the rate-limiting cofactor in mitochondrial ATP synthesis in cardiac cells. Its inclusion supports the energy metabolism underpinning normal cardiovascular function, and its antioxidant properties protect vascular endothelium from oxidative stress — a key driver of vascular inflammation.

Important Notice

Always read the label and follow the directions for use. This product is a complementary medicine and is not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary. Not suitable for use with anticoagulant or antiplatelet medications without medical supervision. Seek professional advice if you have a cardiovascular condition or are taking other medicines.